Sustainable intensification is possible through GxMxE interactions. Genetic manipulations provide improved, high-yielding crop varieties that are tolerant or resistant to abiotic stresses (climate related drought, inundation, heat, cold; soil stresses like acidity and aluminum toxicity, salinity, low fertility, etc.) and biotic constraints (insect pests and diseases). Environment is a given at any location and it cannot be changed completely, but it can be modified to a certain extent to improve crop growth, crop yields, and nutrient contents of produce. Management comes in handy to use the given environment in the bet possible way to grow a crop or to raise livestock. Proper management of crops and resources is critical to to make the production systems sustainable over a long term. Management is also important for efficient production, processing and marketing of products; while at the same time minimizing the impact of farming on resource base (soil, water, biodiversity) and the environment; on greenhouse gas emissions that contribute to climate change, carbon sequestration in soil; and on human health through production of pesticide-free, nutritious foods. Training and technical support are needed for farmers to be good managers of crops and resources. We also need enabling policy environment for farmers to become efficient producers of foods and other commodities.